Vitamin pills can prevent low-weight infants

Last Updated: 2007-04-05 11:30:30 -0400 (Reuters Health)

By Gene Emery

BOSTON (Reuters) - Extra vitamin supplements can reduce the risk of having an underweight or undersized infant, and all pregnant women in developing countries should receive these supplements, researchers said on Wednesday.

But the team, reporting in The New England Journal of Medicine, said the supplements do not reduce the risk of preterm birth or miscarriage.

The study, conducted in Dar es Salaam, Tanzania, involved 8,468 pregnant women without HIV infection and received iron and folic acid supplements. Half were given supplements containing vitamins C, E and a mix of B vitamins. The rest got placebos.

The fetal death rate stayed around 5 percent and the rate of premature delivery was nearly 17 percent, regardless of whether mothers got the vitamins, the team, led by Wafaie Fawzi of Harvard University's School of Public Health, reported.

But the risk of having a low birth-weight baby dropped from 9.4 percent among the placebo recipients to 7.8 percent for the babies whose mothers took the supplements.

"In light of these findings, we recommend that multivitamins be considered for all pregnant women in developing countries, regardless of their HIV status," Fawzi said in a statement.

The team previously found supplements saved the lives of babies of HIV-infected women.

About 20 million low birth-weight babies are born each year, 96 percent of them in developing countries. Babies of low birth weight, defined as less than 5.5 pounds (2,500 grams), are more likely to die young, have growth and learning difficulties and may later be prone to diabetes and heart disease.

"Many developing countries have a system for providing prenatal iron and folate supplements; the supplements are produced in bulk by the United Nations Children's Fund at an estimated cost of less than $1 per person for the duration of the pregnancy," the researchers wrote.

Adding the extra vitamins, they said, would probably increase that cost by just 20 cents, "and scaling up prenatal multiple micronutrient supplementation could be a highly cost-effective approach to improving both outcomes among pregnant women in developing countries."